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Interestingly, the tesofensine-treated rats also had lower levels of dopamine receptors in certain brain regions compared to both the placebo-treated rats and the rats on a restricted diet

Muendlein HI, Connolly WM, Magri Z, Jetton D, Smirnova I, Degterev A, et al

The biological significance isnt just about the peak levelits about sustained receptor occupancy

The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, constipation, and abdominal pain, which typically diminish over time as the body adjusts to the medication

Diabetes Ther 2019;10:232130