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383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)

Utilization impact At the same time, if GLP-1s lead to sustained weight loss and better metabolic health, they could reduce the incidence of costly chronic conditions such as kidney disease or heart failure

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On the other hand, co-treatment with GLP-1 analog exendin-4 caused a significant reduction in the expression of these cytokines