Clinical studies examining this specific combination remain limited, so current evidence relies on mechanism-based reasoning and observational clinical reports rather than large randomized trials
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The Impact of Oxidative Stress in Male Infertility
Reduced secretion of gastric acid and pepsin, from the use of H 2 blocker or proton-pump inhibitor (PPI) drugs, can reduce the absorption of protein-bound (dietary) vitamin B 12 , although not of supplemental vitamin B 12
The primary outcome of this study was overall mortality that was found to be significantly lower among GLP-1RA users (adjusted incidence rate ratio: 0.64, 95% CI:0.560.74) and not influenced by baseline cardiovascular risk, age or HbA1c level at baseline
