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The concern of muscle loss as a side effect One of the most important conversations physicians are having with patients taking GLP-1 medications is how to preserve muscle while losing weight

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One concern is the reduction of lean mass (body weight that is not fat), which has led to speculation that the drug could be lowering muscle mass and strength

A trial published in The Lancet Diabetes & Endocrinology found that semaglutide 1 mg outperformed dulaglutide 1.5 mg in lowering HbA1c and supporting weight loss in people with type 2 diabetes