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Were typically looking at a timeframe of it happening at least once a week for a few months

Thats where the impact concentrates

Heart Beta-blockers bind to beta-adrenoceptors in cardiac nodal tissue, the conducting system, and contracting myocytes

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J Neurosci Res 88(4):905916

Blood for icodec analysis was drawn in Vacuette Z serum clot activator tubes (Greiner Bio-One, Kremsmnster, Austria), allowed to clot for 30 min at room temperature, centrifuged within 1 h of collection at 1500 g for 10 min at 4 C, and serum was then transferred into cryotubes and stored at 20 C until analysis