In summary, our approach demonstrates the feasibility of using peptide-mediated targeting to achieve cell-specific ionotropic receptor modulation and highlights the therapeutic potential of unimolecular mixed GLP-1 receptor agonism and NMDA receptor antagonism for safe and effective obesity treatment
Methods Experimental animals The study was conducted using male TPH1 knockout mice and wild-type C57BL/6 mice (46 weeks, 2126 g) (Animal Feeding Center of Xi'an Jiaotong University Health Science Center)
Ellen Ong-Garcia , Cardiologist and Dr
No study has tested these three together in animals or humans, so the synergy is reasoned from mechanism, not measured
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It interacts with the GHS-R1a receptor, influencing GH pulsatility and appetite-related signaling pathways