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Lastly, a deficiency in vitamin B12 can lead to the inability to lose weight and keep it off for good

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Overweight or obesity (BMI 30-plus, or 27-plus with a weight-related condition) where weight loss is the goal and there is no diabetes driving the choice

Hemoglobin A1c: 3-month average glucose control

[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent