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Insulin Sensitivity Research Research has examined potential relationships between NNMT inhibition and insulin sensitivity in metabolic research models

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As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

Sustained inhibition could have tissue-specific effects that short animal experiments do not fully capture

When NNMT activity is high, research models report: reduced NAD availability for mitochondrial energy production

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