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thus, clinical trials should systematically evaluate dose-dependent efficacy and adverse events to establish optimal therapeutic doses
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Drug Development Pipeline for Genetic Causes of Obesity Rhythm Pharmaceuticals is also developing investigational drugs, RM-718 and bivamelagon, both MC4R agonists for treatment of hypothalamic obesity 15
Future randomized, dermatology-specific trials should stratify by obesity and diabetes status, capture early immunologic and imaging biomarkers, and focus on outcomes that matter directly to patients, such as pain, work and school attendance, and procedure burden
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