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Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats

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The presence of GLP-1 receptors in testicular tissue and evidence of direct, weight-loss-independent effects on sperm function raises the possibility that GLP-1 drugs may act on male reproductive biology through two distinct mechanisms simultaneously: one systemic (through metabolic improvement) and one local (through direct testicular signaling)

This may suggest that patients initiated Mounjaro off-label for overweight or obesity as an alternative to initiating Wegovy on-label due to Wegovy shortages

As the paper notes, patient co-pays for weight-loss treatment are expected to hover around $50 a month on the plans

2, Tables 1, 3)