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The regulatory direction is clear

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Primary Research: Primary research includes discussions with manufacturers, service providers, technology developers, distributors, end users, procurement teams, and subject-matter experts

Cardiovascular, kidney, and safety outcomes with GLP-1RAs alone and in combination with SGLT2is in type 2 diabetes: a systematic review and meta-analysis

And, while the studies may not be as comprehensive as those of their pharmaceutical counterparts, its likely that the touted benefits of some of these supplements are not exclusively the result of a collective placebo effect