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Multiple clinical trials involving young children and adolescents have reported minimal adverse effects

Experimental and molecular pathology , doi: 10.1016/j.yexmp.2014.09.005 (2014)

Side effects, mostly gastrointestinal issues, led between 5% and 10% of participants in the orforglipron study to discontinue treatment, compared with nearly 3% in the placebo group

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Thus, alternative drug candidates (ideally smaller molecules) that can activate the Met signalling cascade are evidently required