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Whilst NAC appears to upregulate endogenous antioxidants in those who have depleted levels, in healthy individuals, high doses may have pro-oxidant effects [107109]

Abbreviations A, amyloid-

Therefore, AIs play a role in minimizing the side effects associated with elevated estradiol levels in men, including gynecomastia (Basaria, 2010)

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Specifically, the increased capillary resistance (due to blockages) causes elevated pressure, resulting in the extracellular release of proteins and lipids that form deposits known as drusen (Kaufmen 2003)