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Microglial NF-kappaB drives tau spreading and toxicity in a mouse model of tauopathy

For the annulus fibrosus (the outer ring of the disc made primarily of collagen), this mechanism may support healing of small tears and prevent further deterioration

Glutamate is converted to -KG both via GLUD1, generating glutamate-derived nitrogen as ammonia, and via aminotransferases, which transfer nitrogen from glutamate to -KG to produce other NEAAs

A final volume of 80 L was frozen and stored at 80 C until required for sequencing

M., Pean, A., Vickers, C

TABLE 1 Microbiota-produced glucoraphanin metabolites in ex vivo studies