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In REDEFINE 1, which enrolled 3,400 adults without diabetes but with at least one weight-related condition, CagriSema led to an average weight loss of 20.4% at Week 68 , compared to 14.9% with semaglutide, 11.5% with cagrilintide, and 3% with placebo

Retatrutide goes one step further because it acts on glucagon (GCG) receptors as well, which also have a role in how hungry you feel

10.1016/S0140-6736(08)61246-5 27 GarveyW

Furness, J

What I didnt know until I started my rabbit hole was that GLP-1 receptors are found on immune cell types like T cells, B cells, macrophages, eosinophils, and on mast cells themselves

Over-interpretation of secondary outcomes may lead to spurious inferences, underscoring the need for caution when translating these findings into clinical reassurance.This aligns with emerging data linking metabolic improvements such as weight loss, insulin sensitivity, and reduced inflammation to decreased malignancy risk in high-risk populations with type 2 diabetes or obesity (Marso et al., 2016a