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injections of 100 nmol kg 1 MK-801 ( n = 7-8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) for 14 days

It is important to note that while the appetite effects are felt quickly, measurable weight loss on the scale may not appear until the end of the first week or even into the second or third week

This exceptional result highlights its potential as one of the most effective anti-obesity therapies in development, underscoring the therapeutic promise of multi-receptor agonists in weight management

Food Chem Toxicol 110:340350

rather, it exemplifies how endogenous peptide systems with pleiotropic signaling can be rendered clinically tractable through advances in peptide stabilization, pharmacokinetics, receptor bias, and dosing strategies

& Lieberman, J