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The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)

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Ilahi S, Beriwal N, Ilahi TB (2023) Physiology, Pineal Gland

He appears pale and dyspneic

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However, their toxicity can vary largely depending on the physicochemical parameters, type of conjugation used, cells studied, etc