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A preclinical study in EBioMedicine reported that tirzepatide reduced alcohol drinking and relapse-like drinking behavior in rodents (8)

Kleiner DE, Brunt EM, Van Natta M et al (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease

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A patient with lower GLP1R pathway activation might benefit more from tirzepatide's dual-peptide action (which targets both GLP-1 and GIP receptors), while someone with strong GLP1R sensitivity may achieve excellent results with standard semaglutide timing

Semaglutide was shown to have a good safety profile and was more tolerated than liraglutide

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