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The MINE creators "arbitrarily created" (their own words, quoted verbatim) minimum and maximum species-wide cutoffs for each of those four echo measurements by the severity of the MVD -- scores 1, 2, 3, and 4 -- based upon "the authors' clinical experience" (again, verbatim)

Anti-MuSK antibodies are of the IgG4 subclass, which is less potent in immune activation and largely circulate with monovalent bispecificity because of a spontaneous Fab arm exchange but may still block the effects of its target [146]

DSIP Dosing Protocol & Schedule Two distinct dosing patterns appear in the DSIP literature

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Trial SURPASS-2 (NEJM 2021) Population 1,879 adults with T2D vs semaglutide 1 mg