Each receptor contributes a distinct metabolic action, and the combination underpins the 24.2% mean weight reduction reported at 48 weeks in the Jastreboff et al
doi:10.1038/s41467-018-03941-2 18
Gallbladder and Biliary Tract Diseases In addition to obesity, rapid and excessive weight loss is known to reduce gallbladder motility, alter bile composition, and thereby predispose individuals to gallstone formation
The New England Journal of Medicine , 387(3), 205216
By adding Glucagon receptor activation , it directly stimulates the liver to burn stored fat (lipolysis) and significantly increases resting energy expenditure (metabolic rate)
The first ingredient, dapagliflozin, belongs to a class of drugs called SGLT2 inhibitors