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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

Their unique ability to target multiple metabolic pathways makes them highly promising for treating T2D and obesity

It is also contraindicated for women who are pregnant or planning to become pregnant

doi: 10.1016/j.neuropharm.2013.08.005 45 KimSMoonMParkS

Clinical trials proving their effectiveness also included education on nutrition and physical activity, which are essential for achieving meaningful results

The Role of GLP-1 Agonists in Esthetic Medicine: Exploring the Impact of Semaglutide on Body Contouring and Skin Health