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They have been shown to reduce serum levels of C-reactive protein (CRP) (by 2038%), lipoprotein-associated phospholipase A2, interleukin (IL)-1 and IL-6 (by 1214%), and tumor necrosis factor-, among others, and boost levels of IL-10, a potent anti-inflammatory cytokine [6468]

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Therefore, a variety of experimental studies and calculations consistently suggest a short half life in the 23 hour range