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2019;7(1):e1108

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Over time, this may lead to needing higher doses to achieve the same outcome or cause a suppressed natural output interval upon discontinuing therapy

On several occasions following pandemics, influenza A cross-reactive immunity has led to a level of protective herd immunity that has eliminated viral subtypes, including H1N1 in 1957, H2N2 in 1968, and seasonal H1N1 in 2009