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The extracellular matrix metabolites play a critical role in wound contraction and tissue regeneration, as highlighted in several studies (Zhao et al., 2015)

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Interestingly, exogenously administered GIP and GLP-1 seem to access the brain predominately via leaks in the bloodbrain barrier, where the underlying neuronal tissue has dense expression of their receptors [11,12,13, 17] (Fig

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