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It is considered to be the key mechanism of ROS-induced sperm damage and leads to Loss of sperm motility Abnormal sperm morphology Reduced capacity for oocyte penetration Infertility To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD)

Interestingly, recent research has highlighted a dual role for Nrf2 in cancer: while basal Nrf2 activity aids normal cell defense, cancer cells can exploit Nrf2 for chemoresistance

Novel roles for protein disulphide isomerase in disease states: A double edged sword

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Cancer 22 , 280297 (2022)