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"Wegovy pill is here, and it represents a significant innovation as the first and only GLP-1 pill for weight loss," said Ed Cinca, senior vice president of marketing at Novo Nordisk

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Trial data indicate that tirzepatide recipients lost an average of 50.3 lb (20.2%), compared with 33.1 lb (13.7%) for those on semaglutide

Cagrilintide as a monotherapy has demonstrated an ability to induce significant body-weight reductions compared with placebo, with synergistic effects when added to semaglutide [52, 53]

However, in two key phase III clinical trials in lung cancer(SKYSCRAPER-01 and SKYSCRAPER-02), the combination therapy did not demonstrate strong synergistic effects [100]