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Incident AF was the primary outcome and captured by a validated algorithm (positive predictive value 69%-77%) based on ICD version 9 code 427.3 or version 10 code I48 in at least two outpatient records within 2 years or in one inpatient record or on problem list, with the earliest date as the event date

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Reported applications include radioligand and fluorescent binding assays at CTR and AMY1 to AMY3, cAMP accumulation and other Gs-pathway readouts, receptor internalisation and regulation studies, and structural biology: Cao and colleagues (Nat Commun, 2025) reported cryo-EM structures of cagrilintide bound to calcitonin and amylin receptors with associated PDB depositions

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