Stretching the limits of extracellular signal-related kinase (ERK) signaling - cell mechanosensing to ERK activation
4 Phytochemical compounds in garlic Approximately 184 diverse types of active secondary metabolites are found in garlic ( 4.1 Bioactive compounds of garlic Due to its many phytochemicals, minerals, and dietary fiber, garlic is considered a valuable spice
In the presence of iron, lipid peroxides turn into toxic lipid free radicals (L-ROS), which leads to the fragmentation of polyunsaturated fatty acids incorporated into phospholipids and cell death (Dixon, 2017)
Cell 134 , 703707 (2008)
The development of high-resolution multidimensional separation techniques such as high-pressure liquid chromatography coupled with a 16-channel coulometric multi-electrode array system (HPLCCMEAS), can lead to revolutionary changes in our understanding at the molecular level ( ANTIOXIDANT DEFENSE SYSTEM GLUTATHIONE REDOX COUPLING AND NITRIC OXIDE SIGNALING Free radicals are unstable atoms or molecules with odd (unpaired) electron(s) that can start a toxic chain reaction on important cellular components such as DNA, or the cell membrane
however, its activity could be reduced since the increase in PDK1 expression observed in bFLS treated with bTNF- 24 , reducing the flux of glucose carbon to the TCA cycle observed in cells treated with TNF-
