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The only FDA-approved treatments (disulfiram, naltrexone, and acamprosate) have been modestly successful in treating AUD (e.g., naltrexone reduces relapse rates by 5%) (for a detailed review and meta-analysis 1,2 ), but still are severely under-prescribed

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GLP-1 is thought to mediate this through inhibiting Rho GTPase in the cyclic adenosine 3,5-monophosphate (cAMP)/protein kinase A (PKA) pathway [25]

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These antibodies can indicate an autoimmune process long before other lab changes become apparent