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Deuring JJ, Fuhler GM, Konstantinov SR et al (2014) Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohns disease

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When the physical barrier of the intestinal epithelium is damaged, intestinal permeability increases, which can easily lead to dysbiosis of the intestinal microbiota, inflammatory reactions, and even systemic diseases

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The degradation of GSH by ChaC1 and the resulting shift in redox potential are key upstream factors that activate calcium signaling, which is essential for the proper development of zebrafish muscles, brain, and heart (Yadav et al., 2019)