Figure 2 Upon admission, the patients CD4 + T-cell count was measured at 329.6 cells/L (indicating moderate immunosuppression), accompanied by severe pulmonary infection, along with prolonged prothrombin time and activated partial thromboplastin time due to APL, elevated D-dimer levels, granulocytopenia, thrombocytopenia, anemia, and other signs suggestive of disseminated intravascular coagulation ( -2 d -1 ) to induce differentiation (while deferring arsenic trioxide (ATO) (0.16mgkg -1 d -1 ) due to the severe lung infection)
Pharmacokinetics: Data indicate a linear pharmacokinetic profile with a short half-life ( 1000mcg/day) have been anecdotally associated with increased chances of headaches, fatigue, or water retention, and may lead to diminishing returns, suggesting a bell-shaped dose-response curve
10.1016/j.biopsych.2020.01.016 121 HainmuellerT.BartosM
Some women may continue taking their medication for several weeks before realizing they are pregnant
Especially popular with patients over 35 who are noticing both slower healing and visible changes in their skin