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Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia

Steroid-sparing treatments, including immunosuppressive agents and biologics such as hydroxychloroquine, can reduce dependence on corticosteroids and limit their associated damage (109)

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Most patients report minimal discomfort

Ceruloplasmin and other copper binding components of blood plasma and their functions: an update