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Fatigue that worsens after meals or is accompanied by abdominal discomfort may primarily reflect gastrointestinal side effects rather than a distinct energy problem

Over time, the body adapts to: Lower calorie intake Reduced hunger signals Altered satiety feedback When medication is stopped suddenly, these adaptations dont disappear gradually they often snap back quickly , creating a biological mismatch between appetite and metabolic capacity

If headaches persist beyond the first week, check whether you are eating enough calories, as appetite suppression from increasing GLP-1 can lead to inadvertent calorie restriction that causes headaches

Working with an obesity medicine specialist can help patients find the safest and most effective path forward

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