BMJ , 374 , n1448
AD is a devastating neurodegenerative disorder characterized by progressive cognitive decline and is frequently accompanied by comorbid symptoms including amnesia, mood and behavioral disturbances, disorientation, language impairment, and, in later stages, motor dysfunction [3,4,5]
Nat Rev Endocrinol 7(11):639 Patel AK, Singhania RR, Pandey A, Chincholkar SB (2010) Probiotic bile salt hydrolase: current developments and perspectives
doi: 10.1080/00325481
P2Y 2 receptor agonists, denufosol (OLIYNYK et al., 2010), were promising for their ability to activate alternative chloride secretion pathways, but both of these agonists have not been pursued further due to not meeting primary study goals of improving FEV 1 (Ratjen et al., 2012) and having a narrow effective concentration range, respectively (OLIYNYK et al., 2010)
10.1016/j.semcancer.2022.12.009 52 HuynhL.HormozdiariF