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Due to the co-occurrence of migraine and gastrointestinal (GI) disorders, this issue has received more attention

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Bacher et al, 2009)

Oxidative stress is a potent, direct trigger for mast cell degranulation

Moreover, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that prevalent users of Ang-II stimulating AHMs had a 25% lower risk of mild cognitive impairment or probable dementia compared to users of Ang-II inhibiting AHMs 12