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And, you know, men can experience the histamine issue with, yeah, when theyre being sexual, because it can cause premature ejaculation if theyve got high levels of histamine inside their blood

The exact mechanisms linking PD and ED are not fully understood, but several factors may contribute to these findings (Figure 2)

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Second, the constipation is dose-related and most prominent during dose escalation, which means timing of any intervention also matters