Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)
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supplements do not Clinical evidence : GLP-1 agonists have extensive randomized controlled trial data
Lingvay I, Manghi FP, Garca-Hernndez P,et al
But they did little to investigate the matter because they believed the spike was caused by a contaminant in preparations of pure insulin
Accessed November 13, 2024 [21] Shrivastava S, Sharma A, Saxena N, Bhamra R, Kumar S