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While the exact prevalence can vary based on the specific medication, dosage, and whether its prescribed for diabetes or weight loss, clinical trials have indicated that between 3% and 32% of participants experience some form of constipation

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Another study found that between 1980 to 2015, sperm counts dropped 57 percent throughout North America, Asia, Europe, and Africa

This is a practical limitation that pushes many users toward 20mg/mL concentration at higher dose levels