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The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]

1992

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The total glucose-lowering effect of TRESIBA over 24 hours measured in a euglycemic clamp study after 8 days of once-daily administration in patients with type 1 diabetes increases approximately in proportion to the dose for doses between 0.4 units/kg to 0.8 units/kg

Buysschaert M, Tennstedt D, Preumont V

Women who consumed 153 g to 400 g of dietary folate per day had a significantly lower chance of developing breast cancer than those who consumed less than 153 g, and more than 400 g