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It is specifically characterized by inflammation, demyelination, and neuronal loss and manifests with a range of neurological symptoms including numbness, tingling, vision impairment, cognitive impairment, and bladder and bowel dysfunction ( In MS, the control of auto-reactive T cells is compromised

Interestingly, neither the site-specifically acetylated SnCE1 variants nor wild type SnCE1 were deacetylated by SnCobB suggesting SnCE1 is deacetylated at the regulated sites after being injected into the host cell by host cell deacetylases (Fig

The single-signal approach is simpler and more predictable