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Ultimately, this review articulates how the zebrafish serves as a unified in vivo system to accelerate the identification and mechanistic validation of plant-derived therapeutics while concurrently de-risking their development, thereby directly contributing to the pipeline for new treatment options in liver disease

Fatty acid synthesis and fatty acid oxidation are known to be important for memory T cell maintenance, with effector T cells being more reliant on glycolysis for ATP generation 26,27,28

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These findings suggest that in the galactose-induced cataract model, oxidative stress induces ER stress, leading to EMT and apoptosis, which, in turn, results in cataracts (Fig

In addition, the observed side-chain flexibility of V12 and F112 indicated that these residues are mainly involved in the overall shaping of the active site and help to position the flavonoid substrate in accordance with the presented structural evidence