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A Crowded Pipeline Means Strategic Differentiation Is Critical With over 100 assets in clinical development, ranging from multi-agonists like retatrutide (with potential for ~25% weight loss) to oral small molecules like orforglipron , the battle for clinical and commercial leadership will be intense [3]

Elmonem MA, Veys KRP, Prencipe G (2022) Nephropathic cystinosis: pathogenic roles of inflammation and potential for new therapies

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Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)

NCT02207374