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Interestingly, studies suggest TrxR inhibitors could also have anti-cancer efficacy due to increased growth rates and elevated cellular ROS from increased mitochondrial respiration that accumulate during accelerated growth resulting in high levels of Trx and TrxR to reduce oxidative stressors (reviewed in Mohammadi et al., 2019)

Chen J, Lou R, Zhou F, Li D, Peng C, Lin L

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