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The histopathological changes in the kidney of the MSG group were defined by membranoproliferative glomerulonephritis and hyaline casts in the Bowmans space and renal tubular lumens (Figures 1C,D)

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In addition, TMP195 continuously activates MAPK and NF-B signaling pathway phosphorylation, suggesting that it promotes M1 polarization through the synergistic action of epigenetic modification and inflammatory signaling pathways (54)