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These agents block the activin type II receptors (ActRIIA and ActRIIB), which are key mediators of muscle catabolism through the myostatin and activin A signaling pathways

While GLP-1 medications can be administered at any time of day (consistent with prescribing information), some patients report personal preference for evening administration

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From there, the retatrutide protocol expands endpoints beyond glucose, insulin, and glucagon to include lipids, appetite hormones, and calorimetry