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When levels drop, the immune system loses some of its responsiveness

NAD+ and Mitochondrial Function in Longevity Research NAD+ (nicotinamide adenine dinucleotide) is a coenzyme with a central role in mitochondrial energy metabolism and DNA repair signaling

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Proteins, including tight junction proteins such as the claudins and occludins control paracellular permeability, defined as the conductance of water and small solutes through the spaces between adjacent epithelial cells [33, 34]

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