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For example, patients with high-activity GLP1R variants may benefit from a more gradual dose escalation to allow better adaptation

While data on tirzepatides long-term cardiovascular outcomes is still developing, early evidence points to comparable benefits, making both options valuable for patients looking to manage weight and enhance heart health simultaneously

10.1210/me.2012-1075 [DOI] [PMC free article] [PubMed] [Google Scholar] Chuang T.-D., Panda H., Luo X., Chegini N

Preventing and treating kidney disease in patients with type 2 diabetes

10.3233/BPL-220141 161 HabaR.ShintaniN.OnakaY.WangH.TakenagaR.HayataA.et al

(Previously, Ozempic was being used for weight loss but had only been approved for diabetes.) In the years following approval, a growing number of household names from Oprah to Elon Musk spoke publicly about their positive experiences using GLP-1s for weight loss