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1,2 Allergic reactions, including anaphylactic shock, are rare and happen more often with injectable forms
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More blood flow delivers nutrition and oxygen to the skin
Chronic inflammation, however, impedes healing and causes progressive tissue damage
It inhibits the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12), modulates the polarization of macrophages towards the M2 (anti-inflammatory) phenotype, and stimulates collagen production in models of pulmonary and cutaneous fibrosis
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