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By blocking NNMT, 5-Amino-1MQ prevents the depletion of NAD+

doi:10.7554/eLife.13185

All mice were observed daily for signs of vaginal opening (VO) which reflects sexual maturation due to increased ovarian activity and estradiol levels and is commonly used as a proxy for pubertal onset [103]

No dose adjustment is required in renal impairment according to the UK SmPC, though renal function should be monitored, especially if significant gastrointestinal adverse effects or dehydration occur