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These opposing effects reflect individual variation in how the digestive system responds to GLP-1 receptor stimulation

Systemic administration of Ex4 (2.4 g/kg, i.p.) significantly decreased oxycodone intake under both schedules and reduced the motivation to obtain the drug, as indicated by a lower breakpoint in PR tests

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Recurrence is described as long as 11 years after the initial surgery

Front Pharmacol 2020;11:589114

Some studies suggest that the beneficial effects of GLP-1RAs can be dampened by the deleterious effects of long-standing T2DM resulting in the reduced capacity to secrete insulin and diminished incretin effects, resulting in reduced glucose-lowering efficacy of GLP-1RA [89, 90]